“Medical & Life Science Seminar, AY2025”

＊Medical & Life Science Seminar, AY2025 / ２０２５年度医学・生命科学セミナー＊

Molecular and neural mechanisms underlying psychosocial stress resilience and susceptibility  

Lecturer

Shusaku UCHIDA

(Professor/ Department of Integrative Stress Science Medical Research Laboratory, Institute of Integrated Research Institute of Science Tokyo)

内田 周作 先生

(東京科学大学 総合研究院難治疾患研究所 統合ストレス医科学分野/教授)

Date

September ３ (Wed) from 5:30 p.m.

令和7年９月３日（水）17:30～

Place: Lecture room 2, Medical Education & Library Building 3F

医学教育図書棟３階 第２講義室

Abstract

A stressful experience can trigger or worsen mental illnesses, such as depression. Depression is a heterogeneous syndrome with variable symptom patterns, course trajectories, and treatment responses. However, the mechanisms by which chronic stress drives individual differences in behavioral patterns remain unclear. Recently, clinical researchers have made extensive efforts to discover subtypes of depression based on biology and/or symptoms to better understand this complex syndrome. Nevertheless, the lack of a subtyping-based approach in preclinical models poses a significant challenge to understanding the neurobiological and pathological implications of psychosocial stress episodes. In this seminar, I will provide an overview of the latest research findings on the molecular and neural mechanisms of stress resilience and susceptibility. I will also present our recent work focusing on individual differences in behavioral responses to chronic stress.